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Longevity & Nootropic

PE-22-28 5mg x 10 vials

Synthetic spadin-derived heptapeptide, a TREK-1 potassium channel inhibitor. Supplied as a sealed box of 10 vials for laboratory research use, sold to approved trade accounts only.
Code PE5Presentation 5mg x 10vialsCategory Longevity & NootropicSizes listed 2Price $85.56
Pricing ladder Prices in CAD · 2 presentations
CodePresentationAvailabilityPer boxPer vialPer mg or unitBoxesLine total
PE55mg x 10vialsMOQ 50$85.56$8.56$1.71 /mg
PE1010mg x 10vialsMOQ 50$153.41$15.34$1.53 /mg

All 2 sizes of PE-22-28 on one page: per box, per vial and per mg, and which sizes are on the shelf.

PE5 in figures 5mg x 10vials
In the box10 vials of 5mg, 50 mg in all. Sold by the sealed box.
Price$85.56 a box, $8.56 a vial, $1.71 /mg. In CAD, freight included from $1,000.00 an order.
Against the other sizesThe 2nd lowest price per mg of the 2 sizes listed. The lowest is PE10, 10mg x 10vials, at $1.53 /mg.
LeavesSpecial order: brought in on a 50-box minimum, not held in stock.
Identity Reference values
NamePE-22-28
Product codePE5
DescriptionSynthetic spadin-derived heptapeptide, a TREK-1 potassium channel inhibitor
CAS number1801959-12-5
Molecular formulaC35H55N11O9
Molecular weight773.89 g/mol
Sequence
GVSWGLR
7 residues. Formula and weight above are calculated from this sequence.
Presentation5mg x 10vials, 10 vials per box
Reference identity for ordering and goods-in checks. The certificate issued with your batch is the controlling document.
Release specification

Every batch is tested against these limits before it is released to stock. A batch that fails any line is quarantined and does not ship.

AppearanceWhite to off-white lyophilised powder or cake, free from foreign matter
IdentityRetention time by RP-HPLC against the reference standard, confirmed by ESI-MS
PurityNot less than 98.0 percent by RP-HPLC, area normalisation at 220 nm
Related substancesAny single related substance not more than 1.0 percent
Water contentNot more than 8.0 percent by Karl Fischer
Acetate contentNot more than 15.0 percent by ion chromatography, where supplied as the acetate
Residual solventsAcetonitrile not more than 410 ppm, TFA not more than 1.0 percent by GC and ion chromatography
Bacterial endotoxinReported on the certificate by LAL where the line is tested
Net contentLabelled peptide content per vial, plus or minus 5 percent by weight
Container and closure2 mL clear moulded glass vial, bromobutyl stopper, aluminium flip-off seal
StorageMinus 20 degrees Celsius, protected from light and moisture. Short transit at ambient is tolerated.
Shelf life24 months from manufacture at minus 20 degrees Celsius, retest date on every certificate
ReconstitutionReconstitute with bacteriostatic or sterile water. Do not shake. Once reconstituted, hold at 2 to 8 degrees Celsius.
Manufacture and documentation
Process routeSolid phase synthesis, preparative RP-HPLC purification, lyophilisation
Batch numberingYear and month of manufacture, product code, then the batch sequence. The number on your vial label, your packing list and the certificate is the same number.
Ships withPacking list showing the batch against every line. Certificate of analysis released with the shipment or on request.
Retained samplesHeld 12 months from dispatch against any query on a batch.
Specification sheetA reference datasheet for this compound, with the release limits and the packing detail, comes from the Download the specification sheet button. It carries no prices, so you can pass it to your own customer.
Look up a batchCertificate lookup takes any batch number from a label or packing list. How a batch is released.
Packing and freight

Freight is included on orders of $1,000.00 and over; below that the checkout quotes the carrier, or a flat $35.00 when no live quote is available, before you pay. The desk books the carrier. The packing list, commercial invoice and batch certificate travel with every shipment; ask for a packing specification if your receiving needs one.

Unit of saleSealed box of 10 vials. Boxes are not split.
Presentation5mg x 10vials
IncotermDAP, delivered in Canada. Freight included on orders of $1,000.00 and over, quoted at checkout below that; nothing is added at dispatch.
CarriersPurolator, FedEx, UPS, Canada Post. Everything ships tracked and plainly packed.

Price and shelf state for PE5 as of , the last day either changed.

About this line

PE5 is PE-22-28 at 5mg a vial: 10 sealed vials to the box, 50 mg in total, $85.56 the box or $1.71 /mg. Of the 2 PE-22-28 sizes on the list it ranks 2nd by price per mg; PE10 (10mg x 10vials) costs least at $1.53 /mg, 10 percent under this line.

PE5 is a special order: it is brought in on a 50-box minimum and not held in stock. None of the 2 sizes is in stock now: 2 special orders on a 50-box minimum. Every vial label repeats the code and the batch number, so the certificate can be pulled from the label alone.

At $85.56 a box, the 50-box minimum on PE5 comes to $4,278.00 of goods, past the $300.00 CAD order minimum on its own. Above it on the ladder is PE10 (10mg x 10vials) at $1.53 /mg, 10 percent under this size.

What the certificate for PE5 must show

Each box of PE5 comes from one batch, and that batch’s certificate carries the lines below before it is released. The limits are the release specification; the sequence notes are worked out from the chain on the sheet.

  • Purity. Not less than 98.0 percent by RP-HPLC, area normalisation at 220 nm, with the main peak named on the chromatogram.
  • Identity. Retention time by RP-HPLC against the reference standard, confirmed by ESI-MS. The spectrometer should place the protonated molecule at m/z 774.9 for 1+, against a calculated average mass of 773.9 (C35H55N11O9); the measured mass should agree to within a unit.
  • Related substances. Any single related substance not more than 1.0 percent. On this sequence the ones to look for are light products of the tryptophan (kynurenine and hydroxytryptophan).
  • Main peak position. On C18 the main peak comes about mid-gradient; the backbone’s Kyte-Doolittle average is 0.14 over 7 residues and the net charge near neutral is about +1.
  • Water. Not more than 8.0 percent by Karl Fischer.
  • Fill. Labelled peptide content per vial, plus or minus 5 percent by weight.
  • Endotoxin. Reported on the certificate by LAL where the line is tested.
  • Batch, dates, signature. The batch number as printed on the vial label and the packing list, the date of manufacture, the retest date (24 months from manufacture at minus 20 degrees Celsius, retest date on every certificate), and the release signature.

Look up a batch number to pull the certificate on file; the signed copy travels with the shipment.

PE-22-28 5mg: what buyers ask

How much does a box of PE-22-28 5mg cost?

$85.56 in CAD for the sealed box of 10 vials, which is $8.56 a vial and $1.71 /mg. Freight included on orders of $1,000.00 and over, quoted at checkout below that.

Is PE5 the cheapest PE-22-28 per mg?

No. PE5 ranks 2nd of 2 by price per mg. PE10 (10mg x 10vials) is lowest at $1.53 /mg, 10 percent under PE5; a bigger vial only pays off if the work uses it.

Can PE5 ship today?

Not from stock. PE5 is a special order: it is brought in on a 50-box minimum and not held in stock, and the date is confirmed when the order is acknowledged.

What is in a box of PE5?

10 sealed vials, each holding 5mg of PE-22-28, 50 mg in the box, packed as a lyophilised powder with the code, the strength and the batch number on every label. The box is the unit of sale and is not opened.

What is on the certificate for a batch of PE5?

In order: purity, identity, related substances, main peak position, water, fill, endotoxin, batch, dates, signature. Each line carries its limit and the batch’s result; the list above is the whole of it, and the batch number on it matches the vial label.

How is PE5 stored after delivery?

Minus 20 degrees Celsius, protected from light and moisture. Short transit at ambient is tolerated. Shelf life is 24 months from manufacture at minus 20 degrees Celsius, retest date on every certificate.

What is the smallest order of PE5?

50 sealed boxes: PE5 is a special order, brought in on a 50-box minimum. The order as a whole must reach $300.00 CAD ($100.00 on a first order), and any mix of lines counts toward it.

Does the PE5 price come down with volume?

Yes, by the order and by the account, and checkout takes the better of the two, never both. A single order takes a volume discount on its goods: 5 percent from $5,000.00, 10 percent from $10,000.00, 15 percent from $20,000.00 and 20 percent from $50,000.00. Lifetime paid spend also moves the account up: Silver from $5,000.00 takes 3 percent off goods, Gold from $15,000.00 takes 6 percent off goods, Platinum from $50,000.00 takes 10 percent off goods, Diamond from $100,000.00 takes 15 percent off goods. On PE5 that runs from $85.56 at list to $68.45 a box at 20 percent off.

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