Gonadorelin research: what the studies have looked at
This page summarises the published research on gonadorelin, for reference. It states what each study investigated and in whom, not an effect to expect, and it is not medical advice. Gonadorelin is approved in some markets, mainly for diagnostic use and ovulation induction; what we supply is a research chemical for laboratory use only.
What gonadorelin is
Gonadorelin is the synthetic form of gonadotropin-releasing hormone (GnRH, also called LHRH), a decapeptide made in the hypothalamus. Formulations have been approved in some markets, for example Factrel and Lutrepulse, mainly as a diagnostic agent and for pulsatile ovulation induction. The material we supply is a research chemical, not an approved medicine, and is not for human or animal use.
What the studies investigated
Belchetz et al. (1978), Science 202(4368):631. Rhesus monkey. Investigated pulsatile versus constant delivery of GnRH Source.
Santoro et al. (1990), American Journal of Obstetrics and Gynecology 163(5):1759. Human, pulsatile administration. Investigated pulsatile gonadorelin for ovulation induction Source.
Sun et al. (2015), Chinese Medical Journal 128(18):2439. Human. Investigated the GnRH stimulation test as a diagnostic tool Source.
Mechanism, as described in the literature
The literature describes gonadorelin as acting on pituitary GnRH receptors to release luteinising hormone and follicle-stimulating hormone, and it makes an important mechanistic point: delivered in pulses it stimulates that axis, while delivered continuously it suppresses it. The cited work covers the foundational primate experiments, human ovulation-induction use and its use as a diagnostic stimulation test.
The material we supply
We supply gonadorelin as a research chemical, released against a written specification with a batch certificate of analysis. It is not an approved medicine and is not for human or animal use. For the vial sizes, the price per mg and how to order, see the gonadorelin compound page; the COA lookup pulls the certificate for any batch. The references above link to each study’s record; this summary is for research and educational reference only.