Cagrilintide research: what the studies have looked at
This page summarises the published research on cagrilintide, for reference. It sets out what each trial tested and in whom, not an outcome for any individual, and it is not medical advice. Cagrilintide is an investigational compound; what we supply under this name is a research chemical for laboratory use only.
What cagrilintide is
Cagrilintide is a long-acting analogue of amylin, a hormone the pancreas releases with insulin. It is in clinical development, both on its own and in a fixed combination with semaglutide known as CagriSema, and it has not been approved by any medicines regulator. Every human figure below comes from a trial, not from routine use, and the material we supply is unapproved research material, not a medicine.
What the studies investigated
Lau et al. (2021), The Lancet 398(10317):2160-2172. Human, phase-2, obesity. Investigated once-weekly cagrilintide dose-finding and body-weight change against placebo Source.
Enebo et al. (2021), The Lancet 397(10286):1736-1748. Human, phase-1b. Investigated cagrilintide combined with semaglutide, reporting safety and pharmacology Source.
D’Ascanio et al. (2024), Cardiology in Review. Review. Reviewed the pharmacology of amylin analogues including cagrilintide Source.
Mechanism, as described in the literature
As an amylin analogue, cagrilintide is described as acting on appetite and gastric emptying through amylin and related receptors, a pathway separate from the GLP-1 system, which is the rationale for pairing it with a GLP-1 agonist. The trials so far measured body weight, safety and pharmacology over fixed windows in defined patient groups; the phase-3 work on the combination is ongoing.
The material we supply
We supply cagrilintide as a research chemical, released against a written specification with a batch certificate of analysis. It is not a medicine and is not for human or animal use. For the vial sizes, the price per mg and how to order, see the cagrilintide compound page; the COA lookup pulls the certificate for any batch. The references above link to each study’s record; this summary is for research and educational reference only.