Kisspeptin-10 research: what the studies have looked at
This page summarises the published research on kisspeptin-10, for reference. It states what each study investigated and in whom, not an effect to expect, and it is not medical advice. Kisspeptin-10 is used in human research but is not an approved medicine; what we supply is a research chemical for laboratory use only.
What kisspeptin-10 is
Kisspeptin-10 is a ten-amino-acid fragment of kisspeptin, a peptide that acts on the KISS1 receptor (also called GPR54) and sits near the top of the hormone cascade that controls reproduction. It has been used as an investigational tool in human endocrine research; it has not been approved as a drug.
What the studies investigated
George et al. (2011), Journal of Clinical Endocrinology and Metabolism 96(8):E1228-E1236. Human, men, intravenous. Investigated the luteinising-hormone response to kisspeptin-10 across doses Source.
Jayasena et al. (2011), Journal of Clinical Endocrinology and Metabolism 96(12):E1963-E1972. Human, men and women. Investigated the hormone response and reported differences between the sexes Source.
Jayasena et al. (2015), Human Reproduction 30(8):1934-1941. Human. Compared kisspeptin-10 with kisspeptin-54 and with GnRH Source.
Mechanism, as described in the literature
Kisspeptin-10 is described as acting on the KISS1 receptor to stimulate the release of gonadotropin-releasing hormone, which in turn drives luteinising hormone and follicle-stimulating hormone. The human studies measured those hormone responses under controlled conditions, as a way of probing the reproductive axis; they are mechanistic and diagnostic, not tests of a treatment.
The material we supply
We supply kisspeptin-10 as a research chemical, released against a written specification with a batch certificate of analysis. It is not a medicine and is not for human or animal use. For the vial sizes, the price per mg and how to order, see the kisspeptin-10 compound page; the COA lookup pulls the certificate for any batch. The references above link to each study’s record; this summary is for research and educational reference only.